| Autor: |
Tegginamani AS; Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia., Shivakumar VH; Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia., Ismail SMB; Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia., Abraham MT; Department of Dentistry, Sentosa Specialist Hospital, Taman Sentosa Perdana, Klang, Selangor, Malaysia., Fernandes BA; Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia., Zamzuri ATB; Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia. |
| Abstrakt: |
Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia's malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic & environmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to differentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required. Key Words: CD 117, Disease progression, Oral dysplasia, Oral leukoplakia, Risk prediction. |
