Novel antiviral effects of chloroquine, hydroxychloroquine, and green tea catechins against SARS CoV-2 main protease (Mpro) and 3C-like protease for COVID-19 treatment.
| Autor: | Shaik FB; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, A.P. India., Swarnalatha K; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, A.P. India., Mohan MC; SB Organics Limited, Hyderabad, Telangana, India., Thomas A; Department of Nursing, Banaswadi College of Nursing, Bangalore, Karnataka, India., Chikati R; Department of Biochemistry, Yogivemana University, Kadapa, 516005, A.P. India., Sandeep G; Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati, 517502, A.P, India., Maddu N; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, A.P. India. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical nutrition open science [Clin Nutr Open Sci] 2022 Apr; Vol. 42, pp. 62-72. Date of Electronic Publication: 2022 Jan 28. |
| DOI: | 10.1016/j.nutos.2021.12.004 |
| Abstrakt: | Objectives: Coronaviruses are globally emerging viruses that threaten our health care systems and have become a popular pandemic around the world. This causes a sudden rise in positive coronavirus cases and related deaths to occur worldwide, representing a significant health hazard to humans and the economy. Methods: We examined predominantly catechins of green tea include epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG), and drugs of chloroquine (CQ), and hydroxychloroquine (HCQ) appearing to reveal anti-viral activities. Data were collected from PubMed, Google Scholar, and Science Direct databases. To investigate the role of antiviral effects (CQ and HCQ), green tea catechins, beneficial use of convalescent plasma; covaxin in COVID-19 patients faced a dangerous healthiness issue. Computational docking analysis has been used for this purpose. Results: The lead compounds are EGCG and ECG act as potential inhibitors bind to the active site region of the HKU4-CoV 3CL protease and M-Pro protease enzymes of coronavirus. Conclusions : SARS-COV-2 is a pathogen of substantial vigour concern and the review unveils the role of catechins associated with many viral diseases. We suggested that the function of green tea catechins, novel drugs of CQ, and HCQ exhibit antiviral activities against positive-sense single-stranded RNA viruses (CoVs). Competing Interests: No other potential conflicts of interest are reported. (© 2022 The Author(s).) |
| Databáze: | MEDLINE |
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