Patients' Experiences With Staphylococcus aureus and Gram-Negative Bacterial Bloodstream Infections: Results From Cognitive Interviews to Inform Assessment of Health-Related Quality of Life.

Autor: King HA; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.; Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.; Division of General Internal Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Doernberg SB; University of California San Francisco Department of Medicine, San Francisco, California, USA., Grover K; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Miller J; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Oakes M; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Wang TW; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., McFatrich M; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Ruffin F; Department of Medicine, Duke University, Durham North Carolina, USA., Staman K; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Lane HG; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Rader A; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Sund Z; Duke Clinical Research Institute, Durham, North Carolina, USA., Bosworth HB; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.; Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.; Division of General Internal Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Reeve BB; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Fowler VG Jr; Department of Medicine, Duke University, Durham North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Holland TL; Department of Medicine, Duke University, Durham North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2021 Dec 08; Vol. 9 (2), pp. ofab622. Date of Electronic Publication: 2021 Dec 08 (Print Publication: 2022).
DOI: 10.1093/ofid/ofab622
Abstrakt: Background: We previously conducted a concept elicitation study on the impact of S taphylococcus aureus and gram-negative bacterial bloodstream infections (SAB/GNB) on health-related quality of life (HRQoL) from the patient's perspective and found significant impacts on HRQoL, particularly in the physical and functional domains. Using this information and following guidance on the development of patient-reported outcome (PRO) measures, we determined which combination of measures and items (ie, specific questions) would be most appropriate in a survey assessing HRQoL in bloodstream infections.
Methods: We selected a variety of measures/items from the Patient-Reported Outcomes Measurement Information System (PROMIS) representing different domains. We purposefully sampled patients ~6-12 weeks post-SAB/GNB and conducted 2 rounds of cognitive interviews to refine the survey by exploring patients' understanding of items and answer selection as well as relevance for capturing HRQoL.
Results: We interviewed 17 SAB/GNB patients. Based on the first round of cognitive interviews (n = 10), we revised the survey. After round 2 of cognitive interviewing (n = 7), we finalized the survey to include 10 different PROMIS short forms/measures of the most salient HRQoL domains and 2 adapted questions (41 items total) that were found to adequately capture HRQoL.
Conclusions: We developed a survey from well-established PRO measures that captures what matters most to SAB/GNB patients as they recover. This survey, uniquely tailored to bloodstream infections, can be used to assess these meaningful, important HRQoL outcomes in clinical trials and in patient care. Engaging patients is crucial to developing treatments for bloodstream infections.
(© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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