An observational study of hospitalized COVID-19 patients with cancer in San Diego county.

Autor: Hermel DJ; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Cham J; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Spierling Bagsic SR; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Hong LK; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Costantini CL; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Mason JR; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Saven A; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA., Sigal DS; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
Jazyk: angličtina
Zdroj: Future oncology (London, England) [Future Oncol] 2022 Feb; Vol. 18 (6), pp. 719-725. Date of Electronic Publication: 2022 Feb 02.
DOI: 10.2217/fon-2021-1116
Abstrakt: Aim: To delineate clinical correlates of COVID-19 infection severity in hospitalized patients with malignancy. Methods: The authors conducted a retrospective review of all hospitalized patients with a hematologic and/or solid tumor malignancy presenting to the authors' institution between 1 March 2020 and 5 January 2021, with a laboratory confirmed diagnosis of COVID-19. Univariate and multivariate logistic regression analyses were used to determine associations between specific severity outcomes and clinical characteristics. Results: Among 2771 hospitalized patients with COVID-19, 246 (8.88%) met inclusion criteria. Patients who were actively receiving treatment had an increased rate of death following admission (odds ratio [OR]: 2.7). After adjusting for significant covariates, the odds ratio increased to 4.4. Patients with cancer involvement of the lungs had a trend toward increased odds of death after adjusting for covariates (OR: 2.3). Conclusions: Among COVID-19 positive hospitalized cancer patients, systemic anti-cancer therapy was associated with significantly increased odds of mortality.
Databáze: MEDLINE
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