Myrsinane-type diterpenes from Euphorbia gedrosiaca with cell growth inhibitory activity and apoptotic effects on melanoma cancer cells.

Autor: Yazdiniapour Z; Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran., Mirian M; Department of Pharmaceutical Biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran., Zolfaghari B; Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran., Mehdifar P; Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran., Ghanadian M; Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Ghannadian@gmail.com., Lanzotti V; Dipartimento di Agraria, Università di Napoli Federico II, Portici, Napoli, Italy. Electronic address: lanzotti@unina.it.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2022 Mar; Vol. 157, pp. 105138. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1016/j.fitote.2022.105138
Abstrakt: Phytochemical analysis of Euphorbia gedrosiaca Rech.f., Aellen & Esfand., an Iranian endemic spurge, afforded the isolation of four myrsinane types diterpene polyesters. Two new compounds (1-2) were based on a myrsinane skeleton while the others (3-4) were known diterpenes based on a cyclomyrsinane backbone. Their chemical structures were elucidated by spectroscopic methods, including 1D and 2D NMR and HRESIMS. The isolated compounds were tested to evaluate their cell growth inhibitory activity and apoptotic effects on melanoma cell lines, B16F10 and A375. The IC 50 values for compounds 1-4 were 58.45, 55.43, 86.52 and 82.27 μM, respectively, on B16F10, and 20.66, 21.88, 36.21 and 39.87 μM, respectively, on A375 cells. Non-treated cells were used as negative control (100% cell growth) and 5 nM Taxol were considered as a positive control.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: