Ophiorrhines F and G, Key Biogenetic Intermediates of Ophiorrhine Alkaloids from Ophiorrhiza japonica and Their Immunosuppressant Activities.

Autor: Shi BB; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Ai HL; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Duan KT; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Feng T; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Liu JK; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
Jazyk: angličtina
Zdroj: Journal of natural products [J Nat Prod] 2022 Feb 25; Vol. 85 (2), pp. 453-457. Date of Electronic Publication: 2022 Feb 01.
DOI: 10.1021/acs.jnatprod.1c01085
Abstrakt: Continued interest in bioactive alkaloids led to the isolation of two undescribed alkaloids, ophiorrhines F ( 1 ) and G ( 2 ), from the aerial parts of Ophiorrhiza japonica. Their structures were elucidated based on spectroscopic methods, electronic circular dichroism, and calculated NMR with DP4+ analysis. These two alkaloids represent key biological genetic intermediates in the formation of ring C in the ophiorrhines. Compound 1 exhibited good inhibition on LPS-induced B cell proliferation with an IC 50 value of 0.38 μM and showed significant selective inhibitory activity on a B cell proliferation response with a selective index of 548.42. A preliminary study indicated that 1 may have a new mechanism of immunosuppression.
Databáze: MEDLINE
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