Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade.

Autor:	Hammer M; David J Apple Laboratory for Vision Research, Heidelberg, Germany., Schickhardt S; David J Apple Laboratory for Vision Research, Heidelberg, Germany., Munro DJ; David J Apple Laboratory for Vision Research, Heidelberg, Germany., Scheuerle A; David J Apple Laboratory for Vision Research, Heidelberg, Germany.; University Eye Hospital Heidelberg, Heidelberg, Germany., Mayer CS; David J Apple Laboratory for Vision Research, Heidelberg, Germany.; University Eye Hospital Heidelberg, Heidelberg, Germany., Auffarth GU; David J Apple Laboratory for Vision Research, Heidelberg, Germany.; University Eye Hospital Heidelberg, Heidelberg, Germany.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2022 Feb 01; Vol. 11 (2), pp. 3.
DOI:	10.1167/tvst.11.2.3
Abstrakt:	Purpose: We studied the effects of exposure to biological media within the eye, such as contamination with lipophilic and amphiphilic substances, on the physicochemical parameters of silicone oil used as an intraocular tamponade. Methods: We removed silicone oil with visible emulsification from 15 patients and measured each sample for shear viscosity and surface tension. We induced in vitro emulsification with balanced salt solution. Using the zeta-potential, we evaluated the emulsion droplet's electrochemical stability. We repeated all experiments in a control group of unused oil. Electrochemical stability and viscosity were additionally measured in oils with high-molecular-weight components. Results: We recovered silicone oils implanted between 30 and 506 days (mean, 196 days). Viscosity did not differ between explanted and control groups. Surface tension and zeta potential remained unchanged (P = 0.61 and P = 0.84, respectively). All oils showed a significant correlation of viscosity with temperature (P < 0.01 for all). Oils with added high-molecular-weight components showed a lower emulsion stability. Conclusions: Prolonged contact to hydrophilic biological media does not alter high-viscosity silicone oil's physicochemical parameters. During typical durations of intraocular use, lipophilic and amphiphilic molecules had no deleterious effect. The addition of high-molecular-weight components might decrease the silicone oil's electrochemical emulsion stability, possibly easing the confluence of emulsion droplets. Translational Relevance: Although the physicochemical parameters of silicone oils are not altered after clinically relevant durations within the eye, emulsion stability significantly differs between oil types.
Databáze:	MEDLINE
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