Cutaneous Manifestations and Hormonal Changes Among Polycystic Ovary Syndrome Patients at a Tertiary Care Center.
| Autor: | Aljefri YE; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU., Alahmadi RA; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Alajmi RS; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU., Alkhamisi TA; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU., Maaddawi HA; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU., Alraddadi AA; Department of Dermatology, King Abdulaziz Medical City, Western Region, Jeddah, SAU., Alamri AM; Department of Dermatology, King Abdulaziz Medical City, Western Region, Jeddah, SAU. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Dec 22; Vol. 13 (12), pp. e20593. Date of Electronic Publication: 2021 Dec 22 (Print Publication: 2021). |
| DOI: | 10.7759/cureus.20593 |
| Abstrakt: | Background: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder affecting 5%-10% of women worldwide. PCOS patients usually present with cutaneous manifestations of hyperandrogenism, such as acne, hirsutism, and androgenic alopecia. Objective: To estimate the prevalence of dermatological manifestations and their association with hormonal changes in PCOS patients. In addition, this study aimed to estimate the prevalence of comorbidities associated with PCOS and to demonstrate the referral pattern among Dermatology, Gynecology, and Primary Health Care (PHC). Methods: This is a cross-sectional study conducted at King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. All PCOS patients who attended KAMC from 2016 to 2021 were included. Data were collected through a retrospective chart review of the electronic medical record system (BestCare) and by utilizing a structured data collection sheet. Results: A total of 447 female patients were diagnosed with PCOS with a median age of 29 years and a median BMI of 28.76 kg/m 2 .The prevalence of cutaneous manifestations among patients was 68%. Hirsutism (47.3%), acne vulgaris (40.6%), and androgenic alopecia (20.3%) were the most common manifestations. The most common hormonal abnormalities were raised luteinizing hormone (LH) levels in 220 (49.1%) patients and raised LH/follicle-stimulating hormone (FSH) ratio in 159 (35.5%) patients. FSH, LH/FSH ratio, and age were significant predictors for acne vulgaris (P-value=0.01, 0.04, and 0.01, respectively). Obesity (44.20%), infertility (25.70%), and dyslipidemia (17%) were the most common comorbidities in our sample. Most patients' first visits and follow-ups were in PHC. Conclusion: The prevalence of cutaneous manifestations among PCOS patients is relatively high and plays a significant role in making the diagnosis. Therefore, physicians across multiple specialties need to be more aware of the full spectrum of PCOS presentations to alleviate it from its under-diagnosed status. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Aljefri et al.) |
| Databáze: | MEDLINE |
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