In vivo safety study using radiation at wavelengths and dosages relevant to intravascular imaging.
| Autor: | Sowers T; Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and Bioscience, Atlant, United States.; Georgia Institute of Technology, George W. Woodruff School of Mechanical Engineering, Atlanta, Georg, United States., VanderLaan D; Georgia Institute of Technology, School of Electrical and Computer Engineering, Atlanta, Georgia, United States., Karpiouk A; Georgia Institute of Technology, School of Electrical and Computer Engineering, Atlanta, Georgia, United States., Onohara D; Emory University Hospital Midtown, Structural Heart Research and Innovation Laboratory, Carlyle Fras, United States., Schmarkey S; Emory University Hospital Midtown, Structural Heart Research and Innovation Laboratory, Carlyle Fras, United States., Rousselle S; StageBio, Mt. Jackson, Virginia, United States., Padala M; Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and Bioscience, Atlant, United States.; Emory University Hospital Midtown, Structural Heart Research and Innovation Laboratory, Carlyle Fras, United States.; Georgia Institute of Technology and Emory University School of Medicine, Wallace H. Coulter Departme, United States., Emelianov S; Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and Bioscience, Atlant, United States.; Georgia Institute of Technology, School of Electrical and Computer Engineering, Atlanta, Georgia, United States.; Georgia Institute of Technology and Emory University School of Medicine, Wallace H. Coulter Departme, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of biomedical optics [J Biomed Opt] 2022 Jan; Vol. 27 (1). |
| DOI: | 10.1117/1.JBO.27.1.016003 |
| Abstrakt: | Significance: Intravascular photoacoustic (IVPA) imaging can identify native lipid in atherosclerotic plaques in vivo. However, the large number of laser pulses required to produce 3D images is a safety concern that has not been fully addressed. Aim: We aim to evaluate if irradiation at wavelengths and dosages relevant to IVPA imaging causes target vessel damage. Approach: We irradiate the carotid artery of swine at one of several energy dosages using radiation at 1064 or 1720 nm and use histological evaluation by a pathologist to identify dose-dependent damage. Results: Media necrosis was the only dose-dependent form of injury. Damage was present at a cumulative fluence of 50 J / cm2 when using 1720 nm light. Damage was more equivocally identified at 700 J / cm2 using 1064 nm. Conclusions: In prior work, IVPA imaging of native lipid in swine has been successfully conducted below the damage thresholds identified. This indicates that it will be possible to use IVPA imaging in a clinical setting without damaging vessel tissue. Future work should determine if irradiation causes an increase in blood thrombogenicity and confirm whether damaged tissue will heal over longer time points. |
| Databáze: | MEDLINE |
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