Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome.

Autor: Barandouzi ZA; School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA.; School of Nursing, Emory University, 1520 Clifton Rd, Atlanta, GA, 30322, USA., Lee J; Department of Statistics, University of Connecticut, 215 Glenbrook Road, U-4120, Storrs, CT, 06269-4120, USA.; Department of Biostatistics and Epidemiology, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19104, USA., Del Carmen Rosas M; School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA., Chen J; School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA.; School of Nursing, University of Maryland, 655 W Lombard St, Baltimore, MD, 21201, USA., Henderson WA; School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA., Starkweather AR; School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA., Cong XS; School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA. xiaomei.cong@uconn.edu.; Biobehavioral Research Laboratory, School of Nursing, University of Connecticut, 231 Glenbrook Road, Unit 4026, Storrs, CT, 06269-4026, USA. xiaomei.cong@uconn.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jan 31; Vol. 12 (1), pp. 1648. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1038/s41598-022-05756-0
Abstrakt: Evidence highlights the comorbidity between emotional distress and irritable bowel syndrome (IBS) through the gut-brain axis. However, the underlying mechanism is largely unknown. Thus, the present study aimed to evaluate the associations among neurotransmitter levels and the gut microbiome profiles in persons with IBS and emotional distress. In this nested case-controlled study, emotional symptoms, including anxiety and depressive symptoms, were evaluated in 40 persons with IBS and 20 healthy controls (HC). Plasma neurotransmitters levels (serotonin and norepinephrine) and the gut microbiome profile of the collected fecal samples were examined. Emotional distress and microbiome profile were significantly different between IBS and HC groups. Lower but not significant neurotransmitters' levels (serotonin and norepinephrine) were observed in the IBS group compared to the HC. A negative correlation was found between norepinephrine levels and alpha diversity (Shannon and Simpson indices) in the IBS group. Moreover, serotonin levels were positively associated with the abundance of Proteobacteria, and norepinephrine were positively correlated with Bacteroidetes, but negatively associated with Firmicutes phylum. The present study demonstrated alteration in the gut microbiome between persons with IBS and emotional distress compared to HC. The correlations between plasma neurotransmitters and the gut microbiome suggest that the gut microbiome may impact the regulation of neurotransmitters.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje