Biomarkers associated with rhythm status after cardioversion in patients with atrial fibrillation.

Autor: Meyre PB; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland. pascal.meyre@usb.ch.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland. pascal.meyre@usb.ch., Aeschbacher S; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Blum S; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Voellmin G; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Kastner PM; Roche Diagnostics GmbH, Penzberg, Germany., Hennings E; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Kaufmann BA; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Kühne M; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Osswald S; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, University Hospital Basel, Spitalstrasse 2, 4031, Basel, Switzerland., Conen D; Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jan 31; Vol. 12 (1), pp. 1680. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1038/s41598-022-05769-9
Abstrakt: Biomarkers may help to improve our knowledge about the complex pathophysiology of atrial fibrillation (AF). In this study we sought to identify significant changes in biomarkers and clinical measures in patients with and without AF recurrence after electrical cardioversion. We measured 21 conventional and new biomarkers before and 30 days after electrical cardioversion and assessed the associations of changes in biomarker levels with rhythm status at follow-up. Significant between-group changes were observed for bone morphogenetic protein 10 (BMP10), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and total bilirubin. Their respective changes were - 10.4%, - 62.0% and - 25.6% in patients with sinus rhythm, and 3.1%, 1.1% and - 9.4% in patients with recurrent AF, for a between-group difference of - 13.5% (95% confidence interval [CI] - 19.3% to - 7.6%; P < 0.001), - 63.1% (95% CI - 76.6% to - 49.6%; P < 0.001) and - 16.3% (95% CI - 27.9% to - 4.7%; P = 0.007). In multivariable models, the reductions of BMP10 and NT-proBNP were significantly associated with follow-up rhythm status (β coefficient per 1 - SD decrease, - 3.85; 95% CI - 6.34 to - 1.35; P = 0.003 for BMP10 and - 5.84; 95% CI - 10.22 to - 1.47; P = 0.009 for NT-proBNP. In conclusion, changes in BMP10 und NT-proBNP levels were independently associated with rhythm status after cardioversion, suggesting that these markers may be dependent on the actual heart rhythm.
(© 2022. The Author(s).)
Databáze: MEDLINE
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