Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4 + T Cell Viability and Proliferation.

Autor:	Crowther RR; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH.; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Schmidt SM; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Lange SM; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., McKell MC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Robillard MC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Zhao J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Haffey WD; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH; and.; Proteomics Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH., Wyder MA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH; and.; Proteomics Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH., Greis KD; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH; and.; Proteomics Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH., Setchell KDR; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Qualls JE; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH; joseph.qualls@cchmc.org.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Feb 15; Vol. 208 (4), pp. 793-798. Date of Electronic Publication: 2022 Jan 31.
DOI:	10.4049/jimmunol.2100652
Abstrakt:	Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synthesis pathway in immune cells; however, its role in APCs has yet to be uncovered. Using a coculture system with mycobacterial-specific CD4 + T cells, we show APC L-ARG synthesis supported T cell viability and proliferation, and activated T cells contained APC-derived L-ARG. We hypothesize that APCs supply L-ARG to support T cell activation under nutrient-limiting conditions. This work expands the current model of APC-T cell interactions and provides insight into the effects of nutrient availability in immune cells. (Copyright © 2022 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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