Impact of lymph node ratio on survival and recurrence outcomes in oral squamous cell carcinoma.

Autor: Mamic M; University of Zagreb School of Medicine, Department of Maxillofacial and Oral Surgery, Dubrava University Hospital, Zagreb, Croatia., Lucijanic M; Department of Haematology, Dubrava University Hospital, Zagreb, Croatia., Lorencin M; University of Zagreb School of Medicine, Department of Maxillofacial and Oral Surgery, Dubrava University Hospital, Zagreb, Croatia., Suton P; Division of Radiation Oncology, Department of Radiotherapy and Medical Oncology, University Hospital for Tumours, University Hospital Centre 'Sisters of Mercy', Zagreb, Croatia., Luksic I; University of Zagreb School of Medicine, Department of Maxillofacial and Oral Surgery, Dubrava University Hospital, Zagreb, Croatia. Electronic address: luksic@kbd.hr.
Jazyk: angličtina
Zdroj: International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2022 Oct; Vol. 51 (10), pp. 1257-1263. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1016/j.ijom.2022.01.009
Abstrakt: Growing evidence supports the lymph node ratio (LNR) as a prognostic factor for survival in patients with oral squamous cell carcinoma (OSCC). However, there is a lack of data regarding its association with recurrence outcomes. Data on 163 patients with OSCC who underwent primary surgical treatment at a tertiary centre between January 2009 and December 2015 were collected retrospectively and analysed. Receiver operating characteristic curve analysis was performed to determine optimal cut-off values for the survival analyses. Survival endpoints were disease progression/relapse for disease-free time (DFT), freedom from loco-regional recurrence (FLR), and freedom from distant metastasis (FDM), and as death from any cause for overall survival (OS). Patients with a lower LNR were found to have significantly superior DFT (LNR < 14%, P < 0.001), FLR (LNR <14%, P < 0.001), FDM (LNR <16%, P = 0.004), and OS (LNR <7%, P = 0.004) in comparison to patients with a higher LNR. LNR is a good predictor of survival and recurrence outcomes in OSCC.
(Copyright © 2022 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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