Measles susceptibility in maternal-infant dyads-Bamako, Mali.

Autor: Dixon MG; Global Immunization Division, US Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: mgdixon@cdc.gov., Tapia MD; Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA., Wannemuehler K; Global Immunization Division, US Centers for Disease Control and Prevention, Atlanta, GA, USA; Department of Biostatistics & Medical Informatics, University of Wisconsin - Madison, WI, USA., Luce R; Expanded Program on Immunization, WHO Regional Office for Africa, Inter-Country Support Team for West Africa, Ouagadougou, Burkina Faso., Papania M; Global Immunization Division, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Sow S; Center for Vaccine Development, Ministry of Health, Bamako, Mali., Levine MM; Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA., Pasetti MF; Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mpasetti@som.umaryland.edu.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2022 Feb 23; Vol. 40 (9), pp. 1316-1322. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1016/j.vaccine.2022.01.012
Abstrakt: Measles is endemic in Africa; measles mortality is highest among infants. Infant measles antibody titer at birth is related to maternal immune status. Older mothers are likelier to have had measles infection, which provides higher antibody titers than vaccine-induced immunity. We investigated the relationship between maternal age and measles susceptibility in mother-infant pairs in Mali through six months of infancy. We measured serum measles antibodies in 340 mother-infant pairs by plaque reduction neutralization test (PRNT) and calculated the proportion of mothers with protective titers (>120 mIU/mL) at delivery and the proportion of infants with protective titers at birth, and at three and six months of age. We explored associations between maternal age and measles antibodies in mothers and infants at the timepoints noted. Ten percent of Malian newborns were susceptible to measles; by six months nearly all were. Maternal and infant antibody titers were highly correlated. At delivery, 11% of mothers and 10% of newborns were susceptible to measles. By three and six months, infant susceptibility increased to 72% and 98%, respectively. Infants born to younger mothers were most susceptible at birth and three months. Time to susceptibility was 6.6 weeks in infants born to mothers with measles titer >120-<430 mIU/mL versus 15.4 weeks when mothers had titers ≥430 mIU/mL. Maternal and newborn seroprotective status were positively correlated. Improved strategies are needed to protect susceptible infants from measles infection and death. Increasing measles immunization coverage in vaccine eligible populations, including nonimmune reproductive-aged women and older children should be considered.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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