Periodontal conditions and incident dementia: A nationwide Swedish cohort study.

Autor: Holmer J; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden., Eriksdotter M; Division of Clinical Geriatrics, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden., Häbel H; Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Hed Myrberg I; Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Jonsson A; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.; Department of Periodontology, Public Dental Care Service at Eastmaninstitutet, Region Stockholm, Stockholm, Sweden., Pussinen PJ; Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Garcia-Ptacek S; Division of Clinical Geriatrics, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden., Jansson L; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.; Department of Periodontology, Public Dental Care Service at Eastmaninstitutet, Region Stockholm, Stockholm, Sweden., Sandborgh-Englund G; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.; Academic Center for Geriatric Dentistry, Stockholm, Sweden., Buhlin K; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.; Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Journal of periodontology [J Periodontol] 2022 Sep; Vol. 93 (9), pp. 1378-1386. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1002/JPER.21-0518
Abstrakt: Background: Periodontal disease has been proposed as a putative etiological factor for dementia. The aim of this investigation was to compare the incidence of dementia in individuals with or without deep probing pocket depths (DPPD), serving as a proxy for periodontitis.
Methods: In this cohort study, conducted in Sweden, we identified 7992 individuals with DPPD and 29,182 matched individuals without DPPD (non-DPPD), using the Swedish Quality Registry for Caries and Periodontal Diseases (SKaPa). The two groups were followed for incident dementia (mean follow-up time was 7.6 years) based on data from the Swedish Dementia Registry (SveDem). The exposure-outcome relationship was explored by applying the Royston-Parmar (RP) flexible parametric survival model.
Results: The incidence of dementia in the two groups was similar. In the DPPD group 137 (1.7%) developed dementia and 470 (1.6%) in the non-DPPD group. The incidence rate of dementia was estimated to be 2.3 per 1000 person-years (95% confidence interval [CI] 1.9 to 2.7) in the DPPD group and 2.1 per 1000 person-years (95% CI 1.9 to 2.3) in the non-DPPD group. The RP model disclosed no association between DPPD and dementia incidence after controlling for potential confounders (the exponentiated coefficient was estimated to 1.13 [95% CI = 0.39 to 3.24]).
Conclusion: In this sample, no association was revealed between deep probing pocket depths and the incidence of dementia.
(© 2021 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.)
Databáze: MEDLINE
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