Quantitative analysis of early retinal vascular changes in type 2 diabetic patients without clinical retinopathy by optical coherence tomography angiography.

Autor: Altinisik M; Ophthalmology Department, Medical School, Manisa Celal Bayar University, Manisa, Turkey. dr.maltinisik@gmail.com., Kahraman NS; Ophthalmology Department, Kayseri Acibadem Hospital, Kayseri, Turkey., Kurt E; Ophthalmology Department, Manisa Celal Bayar University, Manisa, Turkey., Mayali H; Ophthalmology Department, Manisa Celal Bayar University, Manisa, Turkey., Kayikcioglu O; Ophthalmology Department, Manisa Celal Bayar University, Manisa, Turkey.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2022 Feb; Vol. 42 (2), pp. 367-375. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.1007/s10792-022-02230-8
Abstrakt: Purpose: To investigate the quantitative differences in optical coherence tomography angiography (OCTA) data between type 2 diabetes patients without clinically detectable diabetic retinopathy (DR) and healthy subjects.
Methods: Thirty-nine patients with type 2 diabetes without DR and 41 age- and sex-matched healthy controls were recruited. The vessel density and foveal avascular zone (FAZ) area in the superficial capillary plexus and deep capillary plexus were measured using Nidek RS-3000 Advance® and compared between patient cohorts. Foveal vessel density (%) and FAZ (%) were also calculated.
Results: A significant decrease in vessel density has been observed in the deep capillary plexus of the patients compared to healthy individuals (5.58 ± 0.98 mm 2 versus 6.15 ± 0.89 mm 2 , p < 0.001). However, there were no significant differences in other parameters between cohorts (p > 0.05 in all parameters). Despite the decrease of deep capillary plexus density in the macular region, there was no significant change observed in foveal vessel density (p:0.44). It has also been observed that the duration of diabetes mellitus correlates with vessel density decrease in deep capillary plexus (R:-0.52; p < 0.001). In both groups, all parameters in deep capillary plexus were significantly higher than superficial capillary plexus (p < 0.001 for all parameters).
Conclusions: OCTA can identify quantitative changes in DCP before the manifestation of clinically apparent retinopathy. DCP-VD reduction may be an earlier finding than FAZ enlargement. Despite the reduction of VD, FVD could be preserved for a certain period of time in DM patients.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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