Evidence-Based Tools for Dietary Assessments in Nutrition Epidemiology Studies for Dementia Prevention.

Autor: Abbott KA; Prof Gary Frost, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London Hammersmith Campus, Commonwealth Building, Du Cane Road, London W12 ONN, United Kingdom, Tel: +44 (0)20 7594 0959. Fax: +44 (0208383 8320, Email : g.frost@imperial.ac.uk., Posma JM, Garcia-Perez I, Udeh-Momoh C, Ahmadi-Abhari S, Middleton L, Frost G
Jazyk: angličtina
Zdroj: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2022; Vol. 9 (1), pp. 49-53.
DOI: 10.14283/jpad.2022.6
Abstrakt: Increasing evidence proposes diet as a notable modifiable factor and viable target for the reduction of Alzheimer's Disease risk and age-related cognitive decline. However, assessment of dietary exposures is challenged by dietary capture methods that are prone to misreporting and measurement errors. The utility of -omics technologies for the evaluation of dietary exposures has the potential to improve reliability and offer new insights to pre-disease indicators and preventive targets in cognitive aging and dementia. In this review, we present a focused overview of metabolomics as a validation tool and framework for investigating the immediate or cumulative effects of diet on cognitive health.
Competing Interests: JL T Middleton has received research funding (to Institution) from Janssen, Merck (USA), Gates, Takeda/ Millenium, Novartis, Invincro and EIT Health, outside the submitted work. S Ahmadi Abhari and L T Middleton were supported by the European Institute of Innovation and Technology (EIT)-Health for the brain ageing PhD school. J M Posma received a Medical Research Council (MRC) funded HDR UK Rutherford Fund Fellowship (MR/S004033/1). Isabel Garcia-Perez received a NIHR Career Development Research Fellowships (NIHR-CDF-2017-10-032). J M Posma, I Garcia-Perez and G Frost hold a patent in preparation (GB2111739.5) on NMR spectrum data fitting. G Frost – has received research funding (to Imperial College) from Nestle, Unilever, Quorn and Heptaris. G Frost and I Garcia-Perez are directors of Melico Ltd a dietary metabolomic spinout company.
Databáze: MEDLINE
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