The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4 + T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy.

Autor:	Honorato L; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Witkin SS; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, United States., Mendes-Correa MC; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Conde Toscano ALC; Hospital Dia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil., Linhares IM; Departamento de Ginecologia e Obstetrícia, Universidade de São Paulo, São Paulo, Brazil., de Paula AV; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Paião HGO; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., de Paula VS; Laboratory of Molecular Virology, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Lopes AO; Laboratory of Molecular Virology, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Lima SH; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Raymundi VC; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Ferreira NE; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., da Silva Junior AR; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Abrahim KY; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Braz-Silva PH; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.; Faculdade de Odontologia da Universidade de São Paulo, São Paulo, Brazil., Tozetto-Mendoza TR; Laboratory of Virology (LIM 52), Department of Infectious Diseases, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Jan 14; Vol. 8, pp. 809312. Date of Electronic Publication: 2022 Jan 14 (Print Publication: 2021).
DOI:	10.3389/fmed.2021.809312
Abstrakt:	Introduction: Torque teno virus (TTV) is a non-pathogenic virus present in body fluids. Its titer in the circulation increases in association with immune suppression, such as in HIV-infected individuals. We evaluated if the TTV titer in saliva from HIV-positive individuals undergoing antiretroviral therapy (ART) was related to the circulating CD4+ T lymphocyte concentration and the HIV titer. Methods: Saliva was collected from 276 asymptomatic individuals undergoing ART, and an additional 48 individuals positive for AIDS-associated Kaposi's Sarcoma (AIDS-KS). The salivary TTV titer was measured by gene amplification analysis. The circulating CD4+ T lymphocyte and HIV levels were obtained by chart review. Results: TTV was detectable in saliva from 80% of the asymptomatic subjects and 87% of those with AIDS-KS. In the asymptomatic group the median log 10 TTV titer/ml was 3.3 in 200 males vs. 2.4 in 76 females ( p < 0.0001). TTV titer/ml was 3.7 when HIV was acquired by intravenous drug usage, 3.2 when by sexual acquisition and 2.4 when blood transfusion acquired. The salivary TTV titer was inversely correlated with the circulating CD4+ T lymphocyte level ( p < 0.0001) and positively correlated with the circulating HIV concentration ( p = 0.0005). The median salivary TTV titer and circulating HIV titer were higher, and the CD4+ count was lower, in individuals positive for AIDS-KS than in the asymptomatic subjects ( p < 0.0001). Conclusion: The TTV titer in saliva is a potential biomarker for monitoring immune status in individuals undergoing ART. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Honorato, Witkin, Mendes-Correa, Conde Toscano, Linhares, de Paula, Paião, de Paula, Lopes, Lima, Raymundi, Ferreira, da Silva Junior, Abrahim, Braz-Silva and Tozetto-Mendoza.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu