Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus.
| Autor: | Tokajian S; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon., Merhi G; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon., Al Khoury C; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon., Nemer G; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.; Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in microbiology [Front Microbiol] 2022 Jan 13; Vol. 12, pp. 788741. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2021). |
| DOI: | 10.3389/fmicb.2021.788741 |
| Abstrakt: | The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the maxillofacial region, namely mucormycosis, was linked to a deadly infection known as black fungus. Black fungus, diabetes, corticosteroids, and coronavirus disease 2019 (COVID-19) all have a dysregulated immune response in common, which partly could also be attributed to interleukin 37 (IL-37). IL-37, a new cytokine of the IL-1 family, known for broadly reducing innate inflammation as well as acquired immune responses. The use of corticosteroids in diabetic COVID-19 patients, crowded hospitals, and lack of medical oxygen should be carefully considered to reduce COVID-associated secondary infections. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Tokajian, Merhi, Al Khoury and Nemer.) |
| Databáze: | MEDLINE |
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