Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN).
| Autor: | Ye D; Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, USA., Chen H; Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, USA. hongchen@wustl.edu.; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA. hongchen@wustl.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2394, pp. 501-513. |
| DOI: | 10.1007/978-1-0716-1811-0_26 |
| Abstrakt: | The blood-brain barrier (BBB) is the major barrier for brain drug delivery and limits the treatment options for central nervous system diseases. To circumvent the BBB, we introduced the focused ultrasound-mediated intranasal brain drug delivery (FUSIN) technique. FUSIN utilizes the nasal route for direct nose-to-brain drug administration, bypassing the BBB and minimizing systemic exposure. It also uses the transcranial application of ultrasound energy focused at a targeted brain region to induce microbubble cavitation, which enhances the transport of intranasally administered agents at the FUS-targeted brain location. FUSIN is unique in that it can achieve noninvasive and localized brain drug delivery with minimized systemic toxicity. The goal of this chapter is to provide a detailed protocol for FUSIN delivery to the mouse brain. (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Databáze: | MEDLINE |
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