Untangling the placentome gene network of beef heifers in early gestation.

Autor: Diniz WJS; Department of Animal Sciences, Auburn University, Auburn, AL 36849, USA. Electronic address: wzd0027@auburn.edu., Reynolds LP; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Ward AK; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Borowicz PP; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Sedivec KK; Central Grasslands Research and Extension Center, North Dakota State University, Streeter, ND 58483, USA., McCarthy KL; Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Kassetas CJ; USDA NIFA, Kansas City, MO 64105, USA., Baumgaertner F; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Kirsch JD; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Dorsam ST; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Neville TL; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Forcherio JC; Purina Animal Nutrition LLC, Gray Summit, MO 63039, USA., Scott RR; Purina Animal Nutrition LLC, Gray Summit, MO 63039, USA., Caton JS; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA., Dahlen CR; Center for Nutrition and Pregnancy and Department of Animal Sciences, North Dakota State University, Fargo, ND 58102, USA.
Jazyk: angličtina
Zdroj: Genomics [Genomics] 2022 Mar; Vol. 114 (2), pp. 110274. Date of Electronic Publication: 2022 Jan 25.
DOI: 10.1016/j.ygeno.2022.110274
Abstrakt: The cotyledon and caruncle tissues provide a functional bridge between the fetus and the dam. However, the relationship between these tissues and the transcriptomic profile that underlies the tissue functions remains elusive. Herein we investigate the expression profile of cotyledon and caruncle from nulliparous beef heifers carrying female fetuses at day 83 of pregnancy to identify changes occurring across tissues that contribute to placental function and their tissue-specific roles. We identified 2654 differentially expressed genes [padj ≤ 0.05, abs(log2FC) ≥ 1], including nutrient transporters and paternally imprinted genes. We found key regulators of tissue function and differentiation, including FOXO4, GATA2, GATA3, and HAND1, rewired between the tissues. Finally, we shed light on the over-represented pathways related to immune tolerance, tissue differentiation and remodeling. Our findings highlighted the intricate and coordinated cross-talk between fetal-maternal tissues. They provided evidence of a fine-tuned gene regulatory network underlying pregnancy and tissue-specific function in the bovine placenta.
(Published by Elsevier Inc.)
Databáze: MEDLINE