Local seed displacement from Day 0 to Day 30 in I-125 permanent prostate brachytherapy: A detailed, computed tomography-based analysis.

Autor:	Nuver TT; Department of Medical Physics, Radiotherapiegroep, Deventer, the Netherlands. Electronic address: t.nuver@radiotherapiegroep.nl., Hilgers GC; Department of Medical Physics, Radiotherapiegroep, Deventer, the Netherlands., Kattevilder RAJ; Department of Medical Physics, Radiotherapiegroep, Deventer, the Netherlands., Westendorp H; Department of Medical Physics, Radiotherapiegroep, Deventer, the Netherlands.
Jazyk:	angličtina
Zdroj:	Brachytherapy [Brachytherapy] 2022 Mar-Apr; Vol. 21 (2), pp. 208-215. Date of Electronic Publication: 2022 Jan 25.
DOI:	10.1016/j.brachy.2021.12.009
Abstrakt:	Purpose: To accurately quantify local seed displacement from Day 0 to Day 30 for our brachytherapy procedure. To quantify seed loss/migration and to identify the locations from where seeds are missing. Methods and Materials: Seed displacements were analyzed in 62 consecutive patients, who received brachytherapy with stranded I-125 seeds. At the start of the procedure, four fiducial gold markers were implanted. At the end of the implantation procedure an in-room 3D CBCT scan (Day 0) was acquired for accurate seed localization. At Day 30 a regular CT scan was acquired. This CT scan was rigidly registered to the CBCT scan using the fiducials. Subsequently, the Hungarian method was used to find pairs of corresponding seeds. Displacements were calculated and missing seeds were identified. Results: Local seed displacements are smaller than 5 mm for 76.3% of the seeds; 2.3% show displacements larger than 10 mm. The largest seed displacements are seen along the inferior-superior axis: on average 1.0 ± 3.2 mm in superior direction with respect to the intraprostatic fiducials. Largest displacements are seen at the inferior-lateral sides of the prostate. On average, the inferior seeds move 1.0 ± 2.8 mm in anterior and 1.8 ± 3.3 mm in superior direction. The percentage of missing seeds is 0.2% (8 out of 3893 seeds for 5 patients). Most of the missing seeds were also originally implanted at the inferior-lateral sides of the prostate. Conclusions: Local seed displacements and number of missing seeds are small, and predominantly occur around the apex. (Copyright © 2021 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu