Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma.

Autor: Sharbatoghli M; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran., Shamshiripour P; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran., Fattahi F; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran., Kalantari E; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran., Habibi Shams Z; Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran., Panahi M; Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran., Totonchi M; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.; Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran., Asadi-Lari Z; Department of Biology, Faculty of Science, University of Toronto, Toronto, Canada., Madjd Z; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran. zahra.madjd@yahoo.com.; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. zahra.madjd@yahoo.com., Saeednejad Zanjani L; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran. Saeednejad.l@iums.ac.ir.
Jazyk: angličtina
Zdroj: Journal of ovarian research [J Ovarian Res] 2022 Jan 28; Vol. 15 (1), pp. 17. Date of Electronic Publication: 2022 Jan 28.
DOI: 10.1186/s13048-021-00921-x
Abstrakt: Background: Spalt-like transcription factor 4 (SALL4) and aldehyde dehydrogenase1 family member A1 (ALDH1A1) expressing cells have been characterized as possessing stem cell-like properties known as cancer stem cell marker in serous ovarian carcinoma (SOC).
Methods: The association between SALL4 and ALDH1A1 was observed based on literature review and bioinformatics tools. Therefore, this study aimed to investigate the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in SOC patients using immunohistochemical staining on tissue microarrays (TMAs). Furthermore, benign tumors and normal tissue samples were compared with the expression of the tumor tissue samples.
Results: Increased co-expression of SALL4/ALDH1A1 was found to be significantly associated with the advanced FIGO stage (P = 0.047), and distant metastasis (P = 0.028). The results of Kaplan-Meier survival analysis indicated significant differences between disease- specific survival (DSS; P = 0.034) or progression-free survival (PFS; P = 0.018) and the patients with high and low co-expression of SALL4/ALDH1A1, respectively. Furthermore, high level co-expression of SALL4/ALDH1A1 was a significant predictor of worse DSS and PFS in the univariate analysis. The data also indicated that the co-expression of SALL4/ALDH1A1 was an independent prognostic factor affecting PFS. Moreover, the co-expression of SALL4/ALDH1A1 added prognostic values of DSS in patients with SOC who had grade III versus grade I in multivariate analysis.
Conclusions: Our data demonstrated that high co-expression of SALL4/ALDH1A1 was found to be significantly associated with tumor aggressiveness and worse DSS or PFS in SOC patients. Therefore, co-expression of SALL4/ALDH1A1 may serve as a potential prognostic biomarker of cancer progression in these cases.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje