Efficacy of a Carrageenan Gel in Increasing Clearance of Anal Human Papillomavirus Infections in Men: Interim Analysis of a Double-Blind, Randomized Controlled Trial.

Autor:	Laurie C; Division of Cancer Epidemiology, McGill University, Montreal, Canada., El-Zein M; Division of Cancer Epidemiology, McGill University, Montreal, Canada., Tota J; Division of Cancer Epidemiology, McGill University, Montreal, Canada., Khosrow-Khavar F; Division of Cancer Epidemiology, McGill University, Montreal, Canada., Tellier PP; Department of Family Medicine, McGill University, Montreal, Canada., Coutlée F; Laboratoire de virologie moléculaire, Centre de recherche, Centre hospitalier de l'Université de Montréal, et Département de Microbiologie, infectiologie et immunologie, Université de Montréal, Montreal, Canada., de Pokomandy A; Department of Family Medicine, McGill University, Montreal, Canada.; McGill University Health Centre, Montreal, Canada., Franco EL; Division of Cancer Epidemiology, McGill University, Montreal, Canada.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2023 Feb 01; Vol. 227 (3), pp. 402-406.
DOI:	10.1093/infdis/jiac019
Abstrakt:	Preclinical studies have demonstrated carrageenan's anti-human papillomavirus (HPV) activity. We assessed efficacy of a carrageenan-based gel compared to a placebo gel in increasing the clearance of anal HPV infections among gay, bisexual, and other men who have sex with men (gbMSM). Of 255 enrolled gbMSM, 134 were HPV positive at baseline and had valid HPV results for ≥2 visits. Carrageenan did not differ from placebo in clearing all baseline infections (hazard ratio, 0.84 [95% confidence interval, .31-2.27]), based on having 2 consecutive HPV-negative visits following at least 1 HPV-positive visit. There were no remarkable differences for analyses at the HPV type level or by human immunodeficiency virus status. Clinical Trials Registration: NCT02354144. (© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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