Placental infection with SARS-CoV-2, analysis of 16 cases and literature review.

Autor: Dadgar S; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Mahmoudinia M; Department of Obstetrics, Faculty of Medicines, Maternal and Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. mahmoudiniam@mums.ac.ir., Akbari A; Mashhad University of Medical Sciences, Mashhad, Iran., Zandieh E; Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Attaranzadeh A; Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Hoseinpour S; Department of Molecular Genetic, Medical Laboratory, Imam Hosein Hospital, Mashhad, Iran., Jahanpak N; Mashhad University of Medical Sciences, Mashhad, Iran., Tavanaee Sani A; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Mohammadi SA; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Jazyk: angličtina
Zdroj: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2022 May; Vol. 305 (5), pp. 1359-1367. Date of Electronic Publication: 2022 Jan 28.
DOI: 10.1007/s00404-021-06372-5
Abstrakt: Purpose: Since December 2019, the whole world has been affected by coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)]. However, the effects of COVID-19 infection on pregnancy and fetal transmission are still unclear. Therefore, this study was conducted to evaluate placenta samples regarding detection of SARS-CoV-2 RNA in women affected with COVID-19.
Method: This study was a part of a cohort study carried out on pregnant women with a diagnosis of COVID-19 infection who had been admitted to the Imam Reza Hospital in Mashhad, Iran, from March 20 to August 5, 2020. Clinical and laboratory information of all the patients was collected and chest computed tomography (CT) scans were reviewed. Totally, 16 placental tissue were prepared for real time polymerase chain reaction (RT-PCR) testing. All samples were tested by PowerChek PCR real-time kit (South Korea) with 2 target genes (E gene and Rd Rp gene), and Pishtaz Teb kit, (Iran) with 2 target genes (N gene and RdRp gene).
Result: In the first RT-PCR kit by PowerChek kit, 6 samples were positive for a single gene (E gene) and 2 samples were positive for both genes (E gene and Rd Rp gene). In the second RT-PCR kit by Pishtaz Teb kit, 3 samples were positive for two genes (N gene and RdRp gene).
Conclusion: This present study showed that infection of placenta with SARS-CoV-2 may occur in pregnancy. However, whether this infection leads to neonatal infection and serious complication in pregnancy remains unclear.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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