| Autor: |
Van der Auwera G; Institute of Tropical Medicine, Antwerp, Belgium., Davidsson L; The Public Health Agency of Sweden, Solna, Sweden., Buffet P; Service des maladies infectieuses et tropicales, AP-HP, Hopital Necker, Paris, France., Ruf MT; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Gramiccia M; Istituto Superiore di Sanità, Rome, Italy., Varani S; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., Chicharro C; Instituto de Salud Carlos III, Madrid, Spain., Bart A; Amsterdam University Medical Centre, Amsterdam, the Netherlands., Harms G; Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt - Universität zu Berlin, Berlin, Germany., Chiodini PL; Hospital for Tropical Diseases, London, United Kingdom., Brekke H; Oslo University Hospital, Oslo, Norway., Robert-Gangneux F; Univ Rennes, CHU Rennes, Inserm, EHESP, Irset - UMR_S 1085, Rennes, France., Cortes S; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisbon, Portugal., Verweij JJ; Microvida Laboratory for Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands., Scarabello A; National Institute for Infectious Diseases 'Lazzaro Spallanzani', Rome, Italy., Karlsson Söbirk S; Division of Infection Medicine, Lund University, Lund, Sweden., Guéry R; Hôpital privé du Confluent, Nantes, France., van Henten S; Institute of Tropical Medicine, Antwerp, Belgium., Di Muccio T; Istituto Superiore di Sanità, Rome, Italy., Carra E; Istituto Zooprofilattico Sperimentale della Lombardia e dell' Emilia-Romagna 'Bruno Ubertini', Brescia, Italy., van Thiel P; Amsterdam University Medical Centre, Amsterdam, the Netherlands., Vandeputte M; Institute of Tropical Medicine, Antwerp, Belgium., Gaspari V; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Blum J; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland. |
| Abstrakt: |
BackgroundSurveillance of human leishmaniasis in Europe is mostly limited to country-specific information from autochthonous infections in the southern part. As at the end of 2021, no integrated analysis has been performed for cases seen across centres in different European countries.AimTo provide a broad perspective on autochthonous and imported leishmaniasis cases in endemic and non-endemic countries in Europe.MethodsWe retrospectively collected records from cutaneous, mucosal and visceral leishmaniasis cases diagnosed in 15 centres between 2014 and 2019. Centres were located in 11 countries: Belgium, France, Germany, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom. Data on country of infection, reason for travelling, infecting species, age and sex were analysed.ResultsWe obtained diagnostic files from 1,142 cases, of which 76%, 21% and 3% had cutaneous, visceral, and mucosal disease, respectively. Of these, 68% were men, and 32% women, with the median age of 37 years (range: 0-90) at diagnosis. Visceral leishmaniasis was mainly acquired in Europe (88%; 167/190), while cutaneous leishmaniasis was primarily imported from outside Europe (77%; 575/749). Sixty-two percent of cutaneous leishmaniasis cases from outside Europe were from the Old World, and 38% from the New World. Geographic species distribution largely confirmed known epidemiology, with notable exceptions.ConclusionsOur study confirms previous reports regarding geographic origin, species, and traveller subgroups importing leishmaniasis into Europe. We demonstrate the importance of pooling species typing data from many centres, even from areas where the aetiology is presumably known, to monitor changing epidemiology. |
