Transneuronal tracing to map connectivity in injured and transplanted spinal networks.

Autor: Fortino TA; Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America., Randelman ML; Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America., Hall AA; Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America., Singh J; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32608, United States of America., Bloom DC; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32608, United States of America., Engel E; Neuroscience Institute & Viral Core, Princeton University, Princeton, NJ, 08544, United States of America., Hoh DJ; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, 32608, United States of America., Hou S; Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America., Zholudeva LV; Gladstone Institutes, San Francisco, CA, United States of America., Lane MA; Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America. Electronic address: mlane.neuro@gmail.com.
Jazyk: angličtina
Zdroj: Experimental neurology [Exp Neurol] 2022 May; Vol. 351, pp. 113990. Date of Electronic Publication: 2022 Jan 25.
DOI: 10.1016/j.expneurol.2022.113990
Abstrakt: It has become widely appreciated that the spinal cord has significant neuroplastic potential, is not hard-wired, and that with traumatic injury and anatomical plasticity, the networks that we once understood now comprise a new anatomy. Harnessing advances in neuroanatomical tracing to map the neuronal networks of the intact and injured spinal cord has been crucial to elucidating this new spinal cord anatomy. Many new techniques have been developed to identify these networks using a variety of retrograde and anterograde tracers. One method of tracing that has become more widely used to map anatomical changes is transneuronal tracing. Viral tracers are being increasingly used to map spinal networks, leading to an advanced understanding of spinal circuitry and host-donor-host interactions between the injured spinal cord and neural transplants. This review will highlight advances in neuronal tracing, specifically using pseudorabies virus (PRV), and its use in the intact, injured, and transplanted spinal cord.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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