Association between FY*02N.01 and the severity of COVID-19: initial observations.
| Autor: | Conrado MCAV; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil., Dezan MR; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil., Oliveira VB; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil., Ziza KC; Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil., Fanciscani T; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil., Rocha V; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil; Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Churchill Hospital, NHS BT, Oxford University, Oxford, United Kingdom., Mendrone-Júnior A; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil., Dinardo CL; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil; Instituto de Medicina Tropical de São Paulo da Universidade de São Paulo (IMTSP USP), São Paulo, SP, Brazil. Electronic address: caludinardo@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2022 Apr-Jun; Vol. 44 (2), pp. 213-217. Date of Electronic Publication: 2022 Jan 21. |
| DOI: | 10.1016/j.htct.2022.01.002 |
| Abstrakt: | Introduction: The pro-inflammatory immune response underlies severe cases of COVID-19. Antigens of the Duffy blood group systems are receptors for pro-inflammation chemokines. The ACKR1 c.-67T>C gene variation silences the expression of Duffy antigens on erythrocytes and individuals presenting this variant in homozygosity have impaired inflammatory response control. Our aim was to evaluate the association between the ACKR1 c.-67T>C and the severity of COVID-19. Methods: This was a retrospective single-center case-control study, enrolling 164 participants who were divided into four groups: 1) Death: COVID-19 patients who died during hospitalization; 2) Hospital Discharge: COVID-19 patients who were discharged for home after hospitalizations; 3) Convalescent Plasma Donors: COVID-19 patients who were not hospitalized, and; 4) Controls: patients with diagnosis other than COVID-19. Patients were genotyped for the ACKR1 c.-67T>C ( FY*02 N.01 allele) and the frequency of individuals presenting the altered allele was compared between the groups. Results: The groups significantly differed in terms of the percentage of patients presenting at least one FY*02N.01 allele: 36.8% (Death group), 37% (Hospital Discharge group), 16.1% (Convalescent Plasma group) and 16.2% (Control group) ( p = 0.027). The self-declared race ( p < 0.001) and the occurrence of in hospital death ( p = 0.058) were independently associated with the presence of the FY*02N.01 allele. Hypertension ( p < 0.001), age ( p < 0.001) and the presence of at least one FY*02N.01 allele ( p = 0.009) were independently associated with the need for hospitalization. Conclusion: There is a suggestive association between the presence of the FY*02N.01 and the severity of COVID-19. This may be a mechanism underlying the worse prognosis for Afro-descendants infected with SARS-CoV-2. Competing Interests: The authors declare no conflicts of interest. (© 2022 Published by Elsevier España, S.L.U. on behalf of Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular.) |
| Databáze: | MEDLINE |
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