Rapidly Progressive Lung Sarcomatoid Carcinoma Managed with Doxorubicin Plus Ifosfamide and Pemetrexed.

Autor: Paredes Mogica JA; Health Sciences Faculty, Anahuac University, Huixquilucan, Mexico., Reyes Sanchez E; Oncologic research, Centro Oncologico Internacional, Mexico City, Mexico., Zaragoza Morales DA; Health Sciences Faculty, Anahuac University, Huixquilucan, Mexico., Pierre-Louis Guillen N; Health Sciences Faculty, Anahuac University, Huixquilucan, Mexico., Magallanes Maciel ME; Oncologic research, Centro Oncologico Internacional, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Case reports in oncology [Case Rep Oncol] 2021 Nov 25; Vol. 14 (3), pp. 1677-1681. Date of Electronic Publication: 2021 Nov 25 (Print Publication: 2021).
DOI: 10.1159/000520190
Abstrakt: Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of nonsmall-cell lung cancer (NSCLC). It carries a poor prognosis, even among other subtypes of NSCLC. Currently, most treatment strategies for PSC are derived from regimens aimed at managing soft tissue sarcomas or NSCLC. The use of doxorubicin plus ifosfamide and pemetrexed has been well established in the management of soft tissue carcinoma and other nonsmall-cell lung cancers, respectively. We report the case of a 69-year-old male diagnosed with PSC who was managed with doxorubicin plus ifosfamide and pemetrexed therapy. Our patient initially responded to the therapy but had rapid progression and died 8 months after the initiation of treatment. Upon genetic analysis, it was revealed the patient had overexpression of the MDM2 protein, which has been associated with poor response to therapy. This case highlights the need for a personalized treatment approach, as well as the need for a standardized treatment regimen for managing PSC.
Competing Interests: Jan Alberto Paredes Mogica, Eduardo Reyes Sanchez, Daniela Arantza Zaragoza Morales, Nathalie Pierre-Louis Guillen, and Manuel Ernesto Magallanes Maciel had no competing financial interests to disclose.
(Copyright © 2021 by S. Karger AG, Basel.)
Databáze: MEDLINE
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