Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel.

Autor: Mohammed AD; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA.; University of Baghdad School of Veterinary Medicine, Baghdad, Iraq., Mohammed Z; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA.; Al-Mustansiriyah University School of Medicine Department of Microbiology, Baghdad, Iraq., Roland MM; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Chatzistamou I; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Jolly A; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Schoettmer LM; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Arroyo M; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Kakar K; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Tian Y; Pennsylvania State University Department of Veterinary and Biomedical Sciences, State College, PA, USA., Patterson A; Pennsylvania State University Department of Veterinary and Biomedical Sciences, State College, PA, USA., Nagarkatti M; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Nagarkatti P; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA., Kubinak JL; University of South Carolina School of Medicine Department of Pathology, Microbiology, Immunology 6439 Garners Ferry Rd., Columbia, SC, 29209, USA. jason.kubinak@uscmed.sc.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Jan 26; Vol. 13 (1), pp. 525. Date of Electronic Publication: 2022 Jan 26.
DOI: 10.1038/s41467-022-28126-w
Abstrakt: Mucosal antibodies maintain gut homeostasis by promoting spatial segregation between host tissues and luminal microbes. Whether and how mucosal antibody responses influence gut health through modulation of microbiota composition is unclear. Here, we use a CD19 -/- mouse model of antibody-deficiency to demonstrate that a relationship exists between dysbiosis, defects in bile acid homeostasis, and gluten-sensitive enteropathy of the small intestine. The gluten-sensitive small intestine enteropathy that develops in CD19 -/- mice is associated with alterations to luminal bile acid composition in the SI, marked by significant reductions in the abundance of conjugated bile acids. Manipulation of bile acid availability, adoptive transfer of functional B cells, and ablation of bacterial bile salt hydrolase activity all influence the severity of small intestine enteropathy in CD19 -/- mice. Collectively, results from our experiments support a model whereby mucosal humoral immune responses limit inflammatory disease of the small bowel by regulating bacterial BA metabolism.
(© 2022. The Author(s).)
Databáze: MEDLINE
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