Immune-mediated colitis secondary to treatment with nivolumab-ipilimumab in a patient with stage IV kidney cancer: what do we do when corticosteroids fail?

Autor: Sánchez Cánovas M; Hematología y Oncología Médica, Hospital Universitario Jose María Morales Meseguer, España., López Martín A; Aparato Digestivo, Hospital Universitario José María Morales Meseguer., Montenegro Luis S; Hematología y Oncología Médica, Hospital Universitario Jose María Morales Meseguert., Sánchez Saura A; Hematología y Oncología Médica, Hospital Universitario Jose María Morales Meseguer.
Jazyk: angličtina
Zdroj: Revista espanola de enfermedades digestivas [Rev Esp Enferm Dig] 2022 Sep; Vol. 114 (9), pp. 554-555.
DOI: 10.17235/reed.2022.8632/2022
Abstrakt: 52-year-old male. The patient had a stage IV renal carcinoma with bone metastases. He started first-line treatment with nivolumab (3 mg/kg) associated with ipilimumab (1 mg/kg). After two cycles of treatment, the patient reported hemorrhagic diarrhoea (7 to 10 stools daily), with visceral nociceptive abdominal pain of moderate intensity and oral intolerance.
Databáze: MEDLINE