Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections.

Autor: Lodise TP; Albany College of Pharmacy and Health Sciences, Albany, New York, USA., Scheetz M; Midwestern University Chicago College of Pharmacy, Chicago, Illinois, USA., Carreno JJ; Albany College of Pharmacy and Health Sciences, Albany, New York, USA., Chambers H; San Francisco General Hospital, San Francisco, California, USA., Fowler V Jr; Duke Clinical Research Institute, Durham, North Carolina, USA.; Duke University Medical Center, Durham, North Carolina, USA., Holland TL; Duke Clinical Research Institute, Durham, North Carolina, USA.; Duke University Medical Center, Durham, North Carolina, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2022 Jan 22; Vol. 9 (2), pp. ofab651. Date of Electronic Publication: 2022 Jan 22 (Print Publication: 2022).
DOI: 10.1093/ofid/ofab651
Abstrakt: Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400-600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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