Role of Lactobacillus reuteri   DSM 17938 on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study.

Autor: Wadhwa A; Dr. Wadhwa's Clinic, New Delhi 110048, India., Kesavelu D; SS Child Care, Chennai 600037, Tamil Nadu, India., Kumar K; Cloudnine Hospital, Bangalore 560066, Karnataka, India., Chatterjee P; Outreach Clinic, Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, West Bengal, India., Jog P; Medipoint Hospital, Pune 411007, Maharastra, India., Gopalan S; Madhukar Rainbow Children's Hospital, New Delhi 110017, India., Paul R; Outreach Clinic, Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, West Bengal, India., Veligandla KC; Global Generics India, Dr. Reddy's Laboratories Limited, Hyderabad 500016, Telangana, India., Mehta S; Global Generics India, Dr. Reddy's Laboratories Limited, Hyderabad 500016, Telangana, India., Mane A; Global Generics India, Dr. Reddy's Laboratories Limited, Hyderabad 500016, Telangana, India., Pandit S; Global Generics India, Dr. Reddy's Laboratories Limited, Hyderabad 500016, Telangana, India., Rathod R; Global Generics India, Dr. Reddy's Laboratories Limited, Hyderabad 500016, Telangana, India., Jayan S; Medclin Research Pvt. Ltd., Kolkata 700107, West Bengal, India., Mitra M; Institute of Child Health, Kolkata 700017, West Bengal, India.
Jazyk: angličtina
Zdroj: Clinics and practice [Clin Pract] 2022 Jan 07; Vol. 12 (1), pp. 37-45. Date of Electronic Publication: 2022 Jan 07.
DOI: 10.3390/clinpract12010005
Abstrakt: Background: Infantile colic is characterized by prolonged periods of inconsolable, incessant crying and persistent fussing in an otherwise healthy infant. It is a self-limiting condition, but causes significant stress to mothers.
Aim: To observe the role of Lactobacillus reuteri DSM 17938 in reducing crying time in colicky infants in routine clinical practice.
Methods: This was a prospective observational multicentric clinic-based study. Each practitioner included approximately 30 infants < 5 months of age with infantile colic who were prescribed L. reuteri   DSM 17938 for a period of 21 days. There were four physical consultations and two telephonic consultations. The parents were given a daily diary to record the duration of crying and fussing episodes and a questionnaire was administered during the consultations.
Results: A total of 120 infants with a mean age of 56.9 ± 34.2 days were included in this 28-day study. The mean crying time as reported by the parents in the subject diary reduced from 248.2 ± 101.2 min, 95% CI: 229.45, 266.94 at baseline to 45.6 ± 79.1 min 95% CI: 31.02, 60.31 at study end ( P < 0.01). The clinical response (defined as reduction of 50% in crying time) was observed in 85% of subjects at study end. The fussiness and parental perception of colic recorded during the consultations were reduced by 66% and 72%, respectively, at study end. The maternal depression scores were reduced to 63% at study end.
Conclusion: L. reuteri DSM 17938 was associated with a significant reduction in crying time in colicky infants, and showed improvement in maternal depression.
Databáze: MEDLINE
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