The impact of weight cycling on health outcomes in animal models: A systematic review and meta-analysis.

Autor: Thillainadesan S; Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.; Charles Perkins Centre, University of Sydney, Camperdown, New South Wales, Australia.; Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia., Madsen S; Charles Perkins Centre, University of Sydney, Camperdown, New South Wales, Australia.; School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia., James DE; Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.; Charles Perkins Centre, University of Sydney, Camperdown, New South Wales, Australia.; School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia., Hocking SL; Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.; Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Jazyk: angličtina
Zdroj: Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2022 May; Vol. 23 (5), pp. e13416. Date of Electronic Publication: 2022 Jan 25.
DOI: 10.1111/obr.13416
Abstrakt: The pattern of weight loss and regain, termed "weight cycling," is common in overweight individuals. It is unclear whether the well-established benefits of weight loss persist following weight regain or whether weight cycling is harmful. Human studies of weight cycling have conflicting results reflecting limitations of the observational designs of these studies. By controlling the macronutrient content of diets in animal studies, weight cycling can be studied in a highly controlled manner, thereby overcoming the limitations of human studies. We conducted a systematic review and meta-analysis of animal studies which assessed the health consequences of weight cycling. Studies were classified into those which compared weight cycling to lifelong obesity and those which compared weight cycling to later onset obesity. There were no differences in health outcomes between weight cycled animals and those with lifelong obesity, highlighting that weight regain reverses health benefits achieved by weight loss. In comparison with animals with later onset obesity, weight cycled animals had higher fasting glucose levels and more impaired glucose tolerance following weight regain. Our review of animal studies suggests that health benefits of diet-induced weight loss do not persist after weight regain and weight cycling results in adverse metabolic outcomes.
(© 2022 World Obesity Federation.)
Databáze: MEDLINE
Externí odkaz: