Subgenual Anterior Cingulate Cortex Reactivity to Rejection Vs. Acceptance Predicts Depressive Symptoms among Adolescents with an Anxiety History.

Autor: Silk JS; Department of Psychology, University of Pittsburgh., Sequeira SS; Department of Psychology, University of Pittsburgh., Jones NP; Department of Psychology, University of Pittsburgh., Lee KH; Department of Psychiatry, Seoul National University College of Medicine., Dahl RE; School of Public Health, University of California at Berkeley., Forbes EE; Department of Psychology, University of Pittsburgh., Ryan ND; Department of Psychology, University of Pittsburgh., Ladouceur CD; Department of Psychology, University of Pittsburgh.
Jazyk: angličtina
Zdroj: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 [J Clin Child Adolesc Psychol] 2023 Sep 03; Vol. 52 (5), pp. 659-674. Date of Electronic Publication: 2022 Jan 24.
DOI: 10.1080/15374416.2021.2019048
Abstrakt: Objective: The goal of this study was to examine whether neural sensitivity to negative peer evaluation conveys risk for depression among youth with a history of anxiety. We hypothesized that brain activation in regions that process affective salience in response to rejection, relative to acceptance, from virtual peers would predict depressive symptoms 1 year later and would be associated with ecological momentary assessment (EMA) reports of peer connectedness.
Method: Participants were 38 adolescents ages 11-16 (50% female) with a history of anxiety, recruited from a previous clinical trial. The study was a prospective naturalistic follow-up of depressive symptoms assessed 2 years (Wave 2) and 3 years (Wave 3) following treatment. At Wave 2, participants completed the Chatroom Interact Task during neuroimaging and 16 days of EMA.
Results: Controlling for depressive and anxiety symptoms at Wave 2, subgenual anterior cingulate (sgACC; β  = .39, p = .010) activation to peer rejection (vs. acceptance) predicted depressive symptoms at Wave 3. SgACC activation to rejection (vs. acceptance) was highly negatively correlated with EMA reports of connectedness with peers in daily life ( r = - .71, p < .001).
Conclusion: Findings suggest that elevated sgACC activation to negative, relative to positive, peer evaluation may serve as a risk factor for depressive symptoms among youth with a history of anxiety, perhaps by promoting vigilance or reactivity to social evaluative threats. SgACC activation to simulated peer evaluation appears to have implications for understanding how adolescents experience their daily social environments in ways that could contribute to depressive symptoms.
Databáze: MEDLINE
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