Red Blood Cell Distribution Width in Hospitalized COVID-19 Patients.

Autor:	Ramachandran P; Brookdale University Hospital and Medical Center, Brooklyn, NY, United States., Gajendran M; Division of Gastroenterology, Long School of Medicine, University of Texas Health Center at San Antonio, San Antonio, TX, United States., Perisetti A; Interventional Oncology and Surgical Endoscopy (IOSE), Parkview Cancer Center, Parkview Health, Fort Wayne, IN, United States., Elkholy KO; Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, United States., Chakraborti A; Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, United States., Lippi G; Clinical Biochemistry, Laboratory of Clinical Chemistry and Hematology, University Hospital of Verona, University of Verona, Verona, Italy., Goyal H; The Wright Center for Graduate Medical Education, Scranton, PA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Jan 07; Vol. 8, pp. 582403. Date of Electronic Publication: 2022 Jan 07 (Print Publication: 2021).
DOI:	10.3389/fmed.2021.582403
Abstrakt:	Introduction: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases. Objective: To assess if elevated RDW is associated with unfavorable outcomes in hospitalized COVID-19. Methods: We retrospectively studied clinical outcomes of hospitalized COVID-19 patients for their RDW values. In-hospital mortality was defined as primary outcome, while septic shock, need for mechanical ventilation, and length of stay (LOS) were secondary outcomes. Results: A total of 294 COVID-19 patients were finally studied. Overall prevalence of increased RDW was 49.7% (146/294). RDW was associated with increased risk of in-hospital mortality (aOR, 4.6; 95%CI, 1.5-14.6) and septic shock (aOR, 4.6; 95%CI, 1.4-15.1) after adjusting for anemia, ferritin, lactate, and absolute lymphocyte count. The association remained unchanged even after adjusting for other clinical confounders such as age, sex, body mass index, coronary artery disease, hypertension, diabetes mellitus, and chronic obstructive pulmonary disease. No association was found instead with mechanical ventilation and median LOS. Conclusion: Elevated RDW in hospitalized COVID-19 patients is associated with a significantly increased risk of mortality and septic shock. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Ramachandran, Gajendran, Perisetti, Elkholy, Chakraborti, Lippi and Goyal.)
Databáze:	MEDLINE
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