Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma.

Autor: Govoni VM; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University-UNESP, Botucatu, Brazil., Pigoli C; Laboratorio di Istologia, Sede Territoriale di Milano, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna (IZSLER), Milan, Italy.; Department of Veterinary Medicine, University of Milan, Milan, Italy., Sueiro FAR; VetPat Laboratory, Campinas-SP, Brazil., Zuliani F; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University-UNESP, Botucatu, Brazil., da Silva TO; Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Sao Paulo State University-UNESP, Botucatu, Brazil., Quitzan JG; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University-UNESP, Botucatu, Brazil., Laufer-Amorim R; Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Sao Paulo State University-UNESP, Botucatu, Brazil., Grieco V; Department of Veterinary Medicine, University of Milan, Milan, Italy., Fonseca-Alves CE; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University-UNESP, Botucatu, Brazil.; Institute of Health Sciences, Paulista University-UNIP, Bauru-SP, Brazil.
Jazyk: angličtina
Zdroj: Open veterinary journal [Open Vet J] 2021 Oct-Dec; Vol. 11 (4), pp. 535-543. Date of Electronic Publication: 2021 Oct 04.
DOI: 10.5455/OVJ.2021.v11.i4.3
Abstrakt: Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value.
Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC.
Methods: Clinical data of these cases, submitted to São Paulo State University and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin and eosin and histologically evaluated. Survival analysis was carried out, and the prognostic value of the presence of lymphatic invasion and the treatment used was determined.
Results: Dogs with neoplastic lymphatic vessel invasion had a lower overall survival compared to those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared to animals that received carboplatin in addition to surgery.
Conclusion: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.
Competing Interests: The authors declare that they have no conflict of interest.
Databáze: MEDLINE
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