Incomplete Subacute Transverse Myelitis Following Vaccination With Pfizer-BioNTech COVID-19 mRNA Vaccine: A Case Report.
| Autor: | Alabkal J; Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, CAN., Rebchuk AD; Division of Neurosurgery, Faculty of Medicine, University of British Columbia, Vancouver, CAN., Lyndon D; Radiology, Faculty of Medicine, University of British Columbia, Vancouver, CAN., Randhawa N; Division of Neurology, Vancouver General Hospital, Vancouver, CAN. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Dec 16; Vol. 13 (12), pp. e20460. Date of Electronic Publication: 2021 Dec 16 (Print Publication: 2021). |
| DOI: | 10.7759/cureus.20460 |
| Abstrakt: | In response to the coronavirus disease 2019 (COVID-19) pandemic, rapid development, clinical testing, and regulatory approval of vaccines occurred. The tozinameran COVID-19 vaccine is the first mRNA vaccine approved for use in humans. Transverse myelitis is a rare inflammatory disorder of the spinal cord that is associated with traditional vaccinations. There are rare case reports describing an association between mRNA vaccines and transverse myelitis. Herein, we describe a case of transverse myelitis following mRNA vaccination. A healthy 26-year-old woman developed saddle anesthesia, numbness, and allodynia in the S1-S4 distribution within three days of receiving the first dose of tozinameran COVID-19 vaccine. She had decreased sensation to pinprick, temperature, and light touch in S1-S4 distribution and a positive Rhomberg test. An MRI brain and spine demonstrated a short segment T2 hyperintense and diffusely enhancing lesion at T5. Cerebrospinal fluid studies demonstrated pleocytosis and elevated IgG index. A five-day course of IV methylprednisolone resulted in minimal improvements in her symptoms. Stage III clinical trials may be underpowered to detect more rare adverse effects such as transverse myelitis. Therefore, it is imperative to have ongoing surveillance and reporting of adverse events associated with COVID-19 vaccines to ensure transparency with regard to potential risks to patients obtaining the vaccine and algorithms in place for detection and urgent treatment if required. Nonetheless, the safety and efficacy of vaccination against COVID-19 are well established and greatly outweigh any potential risks associated with the vaccine. Given the individual, societal, and global health benefits of vaccination we strongly advocate for ongoing vaccinations against COVID-19. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Alabkal et al.) |
| Databáze: | MEDLINE |
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