Cardiovascular comorbidities in psoriasis (Review).

Autor: Branisteanu DE; Department of Dermatology, Faculty of Medicine 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Nicolescu AC; Department of Dermatology, 'Roma' Medical Center for Diagnosis and Treatment, 011773 Bucharest, Romania., Branisteanu DC; Department of Ophthalmology, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Branisteanu CI; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Dragoi AC; Department of Dermatology, Railway Clinical Hospital, 700506 Iasi, Romania., Bogdanici CM; Department of Ophthalmology, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Toader MP; Department of Oral Dermatology, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Tucaliuc AL; Department of Dermatology, Railway Clinical Hospital, 700506 Iasi, Romania., Dimitriu A; Department of Dermatology, 'Arcadia' Hospitals and Medical Centers, 700620 Iasi, Romania., Daogaru D; Department of Ophthalmology, 'Sf. Spiridon' Clinical Emergency County Hospital, 700111 Iasi, Romania., Pirvulescu RA; Department of Ophthalmology, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Ophthalmology Clinic, Emergency University Hospital, 050098 Bucharest, Romania., Porumb EA; Department of Dermatology, 'Sf. Spiridon' Clinical Emergency County Hospital, 700111 Iasi, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2022 Feb; Vol. 23 (2), pp. 152. Date of Electronic Publication: 2021 Dec 17.
DOI: 10.3892/etm.2021.11075
Abstrakt: Long considered a skin-limited condition, psoriasis is currently defined as a chronic, immune-mediated inflammatory disease, presenting, besides the skin changes, important systemic manifestations, the most common being: psoriatic arthritis, cardiovascular disease, metabolic syndrome, diabetes, inflammatory bowel disease and nonalcoholic steatohepatitis. It is a disease with a strong psycho-emotional and social impact, both through skin changes such as pruritic, scaly erythematous plaques, and through the association of comorbidities that influence morbidity and mortality. It has been shown that psoriasis is an independent cardiovascular risk factor, with patients developing ischemic heart disease/acute coronary syndrome, hypertension, peripheral arterial disease, or stroke. The chronic inflammatory status of psoriasis and the production of specific cytokines may be the etiopathogenic link to atherosclerosis and cardiovascular disease. Biological therapy may affect atherosclerosis, leading to the arrest of the evolution or even regressing the changes in the atheromatous plaque. The aim of this review was to re-evaluate the current knowledge regarding the cardiovascular comorbidities associated with psoriasis for optimal management of the patients.
Competing Interests: All the authors declare that they have no competing interests.
(Copyright: © Branisteanu et al.)
Databáze: MEDLINE
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