Mucosal gene expression profile of stricturing Crohn's disease: A preliminary study.

Autor: Tieranu CG; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania., Olteanu AO; Department of Gastroenterology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania., Preda CM; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania., Bacalbasa N; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Surgery, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania., Milanesi E; Department of Radiobiology, 'Victor Babeş' National Institute of Pathology, 050096 Bucharest, Romania., Dobre M; Department of Pathology, 'Victor Babeş' National Institute of Pathology, 050096 Bucharest, Romania., Tieranu I; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Manuc TE; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania., Klimko A; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Becheanu G; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.; Department of Pathology, 'Victor Babeş' National Institute of Pathology, 050096 Bucharest, Romania., Ionescu EM; Department of Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2022 Feb; Vol. 23 (2), pp. 149. Date of Electronic Publication: 2021 Dec 16.
DOI: 10.3892/etm.2021.11072
Abstrakt: Intestinal strictures are an important complication of Crohn's disease (CD), with ~40% of patients developing symptomatic obstruction within 10 years of diagnosis. However, there is a paucity of research examining the mechanisms driving the development of fibrotic strictures in CD. The present study aimed to identify the mucosal markers associated with stricturing complications by examining the differences in the gene expression profiles of two patient cohorts: Patients diagnosed with inflammatory CD (n=12) and patients with stricturing CD (n=9). For each patient, a paired sample of inflamed and uninflamed mucosa was isolated and assessed by quantitative PCR using a large panel of genes associated with inflammatory bowel disease. The presents study revealed a significantly increased level of four genes in the mucosa of patients with strictures compared with the inflammatory pattern of the disease: Formyl-peptide receptor 1 [P=0.019; fold change (FC)=11.6], C-C chemokine receptor type 1 (P=0.035; FC=5.44), IFN-γ-inducible protein 10 (P=0.037; FC=3.8) and C-C chemokine ligand 25 (P=0.048; FC=3.56). The augmented expression of these four genes in the CD stricturing phenotype, if confirmed in larger cohorts of patients, could help elucidate the mechanisms leading to disease-associated complications.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
Databáze: MEDLINE
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