The effect of low-dose combined hormone therapy (oestradiol and norethindrone acetate) on serum C-reactive protein levels and life quality in natural menopause women.

Autor: Gocer S; Department of Obstetrics and Gynaecology, Okan University School of Medicine, Istanbul, Turkey., Guven S; Department of Obstetrics and Gynaecology, Karadeniz Technical University School of Medicine, Trabzon, Turkey., Sal H; Department of Obstetrics and Gynaecology, Karadeniz Technical University School of Medicine, Trabzon, Turkey., Guven ESG; Department of Obstetrics and Gynaecology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.
Jazyk: angličtina
Zdroj: Przeglad menopauzalny = Menopause review [Prz Menopauzalny] 2021 Dec; Vol. 20 (4), pp. 177-183. Date of Electronic Publication: 2021 Nov 24.
DOI: 10.5114/pm.2021.110935
Abstrakt: Introduction: To assess the effect of low-dose combined oestradiol and norethindrone acetate hormone therapy (HT) on serum C-reactive protein (CRP) levels and life quality in natural menopause women.
Material and Methods: Forty-five natural menopause women admitted to the clinic during a 1-year period and diagnosed as menopause, who planned to have HT for menopausal symptoms, were enrolled in this prospective study. The serum CRP levels were measured, and vasomotor symptoms scores were graded according to the Blatt-Kupperman menopause index, and life quality scores according to the Menopause-Specific Quality of Life Questionnaire (MENQOL) were recorded before and after (3 months later) hormone therapy.
Results: The Blatt-Kupperman menopause index and MENQOL scores were significantly decreased after 3 months of low-dose treatment. No significant difference was found between white blood cell counts and serum CRP levels before and after 3 months of hormone therapy.
Conclusions: Considering all HT types and biochemical effects, low-dose HT, which had positive results in terms of quality of life, was a safe treatment and could be preferred to conventional-dose preparations in cases without contraindications. Low-dose combined HT containing oestradiol and norethindrone acetate did not alter the serum CRP level in postmenopausal cases.
Competing Interests: The authors report no conflict of interest.
(Copyright © 2021 Termedia.)
Databáze: MEDLINE
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