Continuous Hemodiafiltration with the oXiris Filter Ameliorates Cytokine Storm and Induces Rapid Clinical Improvement in COVID-19 - A Case Report.

Autor: Lobo VA; Renal Unit, Department of Medicine, King Edward Memorial Hospital, Pune, Maharashtra, India., Lokhande A; Division of Critical Care, Department of Medicine, King Edward Memorial Hospital, Pune, Maharashtra, India., Chakurkar V; Renal Unit, Department of Medicine, King Edward Memorial Hospital, Pune, Maharashtra, India., D'Costa PM; Division of Critical Care, Department of Medicine, King Edward Memorial Hospital, Pune, Maharashtra, India.
Jazyk: angličtina
Zdroj: Indian journal of nephrology [Indian J Nephrol] 2021 Nov-Dec; Vol. 31 (6), pp. 555-558. Date of Electronic Publication: 2021 Apr 07.
DOI: 10.4103/ijn.IJN_429_20
Abstrakt: Delayed interferon secretion and cytokine dysregulation are responsible for the life-threatening acute respiratory distress syndrome (ARDS), multiorgan dysfunction and shock in COVID 19, which closely resembles secondary hemophagocytic lymphohistiocytosis (sHLH). IL-6, a marker of hypercytokinemia in patients with COVID-19 is positively correlated with disease severity, development and progression of ARDS, and mortality. Therapy to either reduce IL-6 or inhibit its action with either non-specific inhibitors of inflammation like dexamthasone or Toclizumab a specific inhibitor of IL-6 has produced decrease in mortality. We describe a novel method of treatment in a patient with multiorgan involvement in COVID 19, using the oXiris hemofilter which delivers renal replacement therapy while also reducing cytokines like IL-6.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2021 Indian Journal of Nephrology.)
Databáze: MEDLINE
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