Lower transfer factor of the lung for carbon monoxide in women with a patent foramen ovale.

Autor: Schallerer AE; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Duke JW; Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA., Speros JP; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Mangum TS; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Norris HC; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Beasley KM; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA., Laurie SS; KBR, Cardiovascular and Vision Laboratory, NASA Johnson Space Center, Houston, Texas, USA., Elliott JE; VA Portland Health Care System, Portland, Oregon, USA.; Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA., Davis JT; Department of Kinesiology, Recreation and Sport, Indiana State University, Terre Haute, Indiana, USA., Lovering AT; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Jazyk: angličtina
Zdroj: Experimental physiology [Exp Physiol] 2022 Mar; Vol. 107 (3), pp. 243-252. Date of Electronic Publication: 2022 Feb 17.
DOI: 10.1113/EP090176
Abstrakt: New Findings: What is the central question of this study? Do individuals with a patent foramen ovale (PFO + ) have a lower lung transfer factor for carbon monoxide than those without (PFO - )? What is the main finding and its importance? We found a lower rate constant for carbon monoxide uptake in PFO + compared with PFO - women, which was physiologically relevant (≥0.5 z-score difference), but not for PFO + versus PFO - men. This suggests that factors independent of the PFO are responsible for our findings, possibly inherent structural differences in the lung.
Abstract: The transfer factor of the lung for carbon monoxide (TL CO ) measure assumes that all cardiac output flows through the pulmonary circuit. However, right-to-left blood flow through a shunt can result in a lower transfer factor than predicted. A patent foramen ovale (PFO) is a potential source of right-to-left shunt that is present in ∼35% of the population, but the effect of PFO on TL CO is unknown. We sought to determine the effect of PFO on the TL CO . We conducted a retrospective analysis of TL CO data from 239 (101 women) participants. Anthropometrics and lung function, including spirometry, plethysmography and TL CO , were compiled from our previously published work. Women, but not men, with a PFO had a significantly lower TL CO and rate constant for carbon monoxide uptake (K CO ) (percentage of predicted and z-score) than women without a PFO. Women and men with a PFO had normal alveolar volumes that did not differ from those without a PFO. Correcting the data for haemoglobin in a subset of subjects did not change the results (n = 58; 25 women). The lower K CO in women with versus without a PFO was physiologically relevant (≥0.5 z-score difference). There was no effect of PFO in men. This suggests that factors independent of the PFO are responsible for our findings, possibly inherent structural differences in the lung.
(© 2022 The Authors. Experimental Physiology © 2022 The Physiological Society.)
Databáze: MEDLINE
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