Practical approaches to labelling terminal alkynes with deuterium.

Autor: Chan MYT; Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK., Anwar A; Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK., Lockley WJS; Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK.
Jazyk: angličtina
Zdroj: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2022 Apr; Vol. 65 (4), pp. 101-111. Date of Electronic Publication: 2022 Feb 02.
DOI: 10.1002/jlcr.3963
Abstrakt: Base catalysed exchange with sodium hydroxide, calcium oxide or N,N,N,N-tetramethylguanidine in deuterium oxide is a viable procedure for the preparation of terminally deuterated alkynes for those alkynes stable to strong base. The use of silver perchlorate as a catalyst is an alternative practical option when labelling alkynes which are sensitive to base or contain functionalities which would lead to labelling elsewhere in the molecule. Labelling with this catalyst takes place smoothly at ambient temperature in a mixture of N,N-dimethylformamide and deuterium oxide.
(© 2022 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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