Cardiometabolic factors and risk of non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.

Autor: Chatziralli IP; 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, 1, Rimini Street, Haidari, 12462, Athens, Greece. eirchat@yahoo.gr., Kazantzis D; 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, 1, Rimini Street, Haidari, 12462, Athens, Greece., Chatzirallis AP; 2nd Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece., Machairoudia G; 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, 1, Rimini Street, Haidari, 12462, Athens, Greece., Papageorgiou EG; Department of Biomedical Sciences, University of West Attica, Athens, Greece., Theodossiadis GP; 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, 1, Rimini Street, Haidari, 12462, Athens, Greece., Psaltopoulou T; Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Theodossiadis PG; 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, 1, Rimini Street, Haidari, 12462, Athens, Greece., Sergentanis TN; Department of Biomedical Sciences, University of West Attica, Athens, Greece.; Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2022 May; Vol. 260 (5), pp. 1445-1456. Date of Electronic Publication: 2022 Jan 24.
DOI: 10.1007/s00417-021-05522-4
Abstrakt: Purpose: The purpose of this systematic review and meta-analysis of the literature is to evaluate the association between cardiometabolic risk factors (hypertension, diabetes mellitus, hypercholesterolemia/dyslipidemia, HDL cholesterol, LDL cholesterol, lipoprotein(a), and triglycerides) and non-arteritic anterior ischemic optic neuropathy (NAION).
Methods: Pertinent publications were identified through a systematic search in PubMed and EMBASE databases, without language restrictions. The pooled odds ratios (OR) and standardized mean differences (SMD), with their 95% confidence intervals (95% CI) were estimated using random effects (DerSimonian Laird) models, as appropriate. A set of subgroup analyses and meta-regression analysis models were performed.
Results: Twenty-one studies (including 1560 patients with NAION and 2292 controls), examining the association between NAION and cardiometabolic risk factors, were eligible for the systematic review and meta-analysis. Hypertension (pooled OR = 1.50; 95% CI: 1.16-1.94), diabetes mellitus (pooled OR = 1.71; 95% CI: 1.33-2.21), and hypercholesterolemia/dyslipidemia (pooled OR = 2.00; 95% CI: 1.53-2.62) were associated with NAION. Among the components of dyslipidemia, higher serum triglycerides were associated with NAION, with a medium effect size (SMD =  + 0.58, 95% CI: + 0.12 to + 1.04), whereas synthesis of four studies reporting on HDL and LDL cholesterol did not reveal any significant associations. A significant association between NAION and higher serum lipoprotein(a) levels (pooled OR = 2.88; 95%CI: 1.01-8.21) was also noted.
Conclusions: This systematic review and meta-analysis found that NAION was associated with cardiometabolic factors, suggesting that vascular dysfunction may be implicated in the pathogenesis of the disease. Our findings may alert health care providers to try modifying these risk factors for NAION prevention.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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