SOD mimics: From the tool box of the chemists to cellular studies.

Autor: Policar C; Laboratoire de BioMolécules (LBM), Département de Chimie, Sorbonne Université, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005, Paris, France. Electronic address: clotilde.policar@ens.psl.eu., Bouvet J; Laboratoire de BioMolécules (LBM), Département de Chimie, Sorbonne Université, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005, Paris, France., Bertrand HC; Laboratoire de BioMolécules (LBM), Département de Chimie, Sorbonne Université, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005, Paris, France., Delsuc N; Laboratoire de BioMolécules (LBM), Département de Chimie, Sorbonne Université, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005, Paris, France.
Jazyk: angličtina
Zdroj: Current opinion in chemical biology [Curr Opin Chem Biol] 2022 Apr; Vol. 67, pp. 102109. Date of Electronic Publication: 2022 Jan 20.
DOI: 10.1016/j.cbpa.2021.102109
Abstrakt: Superoxide dismutases (SODs) are metalloproteins that protect cells against oxidative stress by controlling the concentration of superoxide (O 2 - ) through catalysis of its dismutation. The activity of superoxide dismutases can be mimicked by low-molecular-weight complexes having potential therapeutic applications. This review presents recent strategies for designing efficient SOD mimics, from molecular metal complexes to nanomaterials. Studies of these systems in cells reveal that some SOD mimics, designed to react directly with superoxide, may also indirectly enhance the cellular antioxidant arsenal. Finally, a good understanding of the bioactivity requires information on the cell-penetration, speciation, and subcellular location of the SOD mimics: we will describe recent studies and new techniques that open opportunities for characterizing SOD mimics in biological environments.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: