High-fat/high-carbohydrate-diet short- and middle-term effects on gerbil adrenal zona fasciculata histology.

Autor: Bellahreche Z; LBPO/ Nutrition & Metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), BP 32, El Alia Bab Ezzouar, 16111, Algiers, Algeria. Electronic address: zinebbelllahreche@gmail.com., Semiane N; LBPO/ Nutrition & Metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), BP 32, El Alia Bab Ezzouar, 16111, Algiers, Algeria., Mallek A; LBPO/ Nutrition & Metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), BP 32, El Alia Bab Ezzouar, 16111, Algiers, Algeria., Dahmani Y; LBPO/ Nutrition & Metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), BP 32, El Alia Bab Ezzouar, 16111, Algiers, Algeria.
Jazyk: angličtina
Zdroj: Tissue & cell [Tissue Cell] 2022 Apr; Vol. 75, pp. 101729. Date of Electronic Publication: 2022 Jan 08.
DOI: 10.1016/j.tice.2022.101729
Abstrakt: The adrenals synthesize many hormones involved in the regulation and maintenance of homeostasis. To understand the pathophysiological changes during the development of obesity, a histological study of the adrenal was performed in gerbils receiving a high-fat/high-carbohydrate-diet (HFC) for 8 or 12 weeks. Compared to the controls, the HFC diet increased body weight. Our results reveal significant weight and structural changes in the HFC group's adrenal glands (confirmed by gray level co-occurrence matrix texture and fractal analysis), disorganization of zona fasciculata (8 weeks) and hyperplasia and peri-capillary fibrosis (12 weeks). In conclusion, these results show that an HFC induces time-dependent structural lesions of the adrenals in gerbils, which could be a sign of chronic adaptation of these glands.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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