Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS-CoV-2 Patients.
Autor: | Pvsn KK; Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan, 342005, India., Tomo S; Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan, 342005, India., Purohit P; Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan, 342005, India., Sankanagoudar S; Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan, 342005, India., Charan J; Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India., Purohit A; Department of Pathology, All India Institute of Medical Sciences, Jodhpur, India., Nag V; Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, India., Bhatia P; Department of Anaesthesia, All India Institute of Medical Sciences, Jodhpur, India., Singh K; Department of Paediatrics, All India Institute of Medical Sciences, Jodhpur, India., Dutt N; Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India., Garg MK; Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, India., Sharma P; Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan, 342005, India., Misra S; Department of Surgical Oncology, Director and CEO, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Yadav D; Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan, 342005, India. dharam143s@gmail.com. |
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Jazyk: | angličtina |
Zdroj: | Biological trace element research [Biol Trace Elem Res] 2023 Jan; Vol. 201 (1), pp. 23-30. Date of Electronic Publication: 2022 Jan 22. |
DOI: | 10.1007/s12011-022-03124-7 |
Abstrakt: | The deficiencies of trace elements and infectious diseases often coexist and exhibit complex interactions. Several trace elements such as zinc (Zn), copper (Cu) and magnesium (Mg) have immunomodulatory functions and thus influence the susceptibility to the course and outcome of a variety of viral infections. So, this present study was aimed to study relations of trace metals in association with severity and mortality in SARS-CoV-2 patients. A total of 150 individuals infected with COVID-19 and 50 healthy individuals were recruited. Cases were divided based on severity (mild, moderate and severe) and outcome (discharged or deceased). Serum Zn, Mg and Cu levels were analysed by direct colourimetric method. Both serum Cu and Zn levels were significantly decreased in cases when compared to those in controls (p < 0.005 and p < 0.0001). Serum magnesium levels although not significant were found to be slightly decreased in controls. On comparing the trace elements between the deceased and discharged cases, a significant difference was found between serum copper and zinc levels, but for magnesium, both groups have similar levels. The receiver operating characteristic (ROC) curve results indicate that a serum Cu/Zn ratio along with the age of patient provides some reliable information on COVID-19 course and survival odds by yielding an AUC of 95.1% with a sensitivity of 93.8% and specificity of 89.8%. Therefore, we would like to emphasize that measuring the serum copper and zinc along with their ratio can be used as routine investigations for COVID-19 patients in proper identification and management of severe cases in upcoming new waves of COVID-19. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
Databáze: | MEDLINE |
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