Outdoor ambient air pollution and breast cancer survival among California participants of the Multiethnic Cohort Study.

Autor: Cheng I; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, San Francisco, CA, USA. Electronic address: iona.cheng@ucsf.edu., Yang J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Tseng C; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wu J; Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, Irvine, CA, USA., Conroy SM; Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA., Shariff-Marco S; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, San Francisco, CA, USA., Lin Gomez S; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, San Francisco, CA, USA., Whittemore AS; Stanford University School of Medicine, Stanford, CA, USA., Stram DO; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Le Marchand L; Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA., Wilkens LR; Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA., Ritz B; Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA., Wu AH; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2022 Mar; Vol. 161, pp. 107088. Date of Electronic Publication: 2022 Jan 18.
DOI: 10.1016/j.envint.2022.107088
Abstrakt: Background: Within the Multiethnic Cohort (MEC), we examined the association between air pollution and mortality among African American, European American, Japanese American, and Latina American women diagnosed with breast cancer.
Methods: We used a land use regression (LUR) model and kriging interpolation to estimate nitrogen oxides (NO x , NO 2 ) and particulate matter (PM 2.5 , PM 10 ) exposures for 3,089 breast cancer cases in the MEC, who were diagnosed from 1993 through 2013 and resided largely in Los Angeles County, California. Cox proportional hazards models were used to examine the association of time-varying air pollutants with all-cause, breast cancer, cardiovascular disease (CVD), and non-breast cancer/non-CVD mortality, accounting for key covariates.
Results: We identified 1,125 deaths from all causes (474 breast cancer, 272 CVD, 379 non-breast cancer/non-CVD deaths) among the 3,089 breast cancer cases with 8.1 years of average follow-up. LUR and kriged NO X (per 50 ppb) and NO 2 (per 20 ppb), PM 2.5 (per 10 µg/m 3 ), and PM 10 (per 10 µg/m 3 ) were positively associated with risks of all-cause (Hazard Ratio (HR) range = 1.13-1.25), breast cancer (HR range = 1.19-1.45), and CVD mortality (HR range = 1.37-1.60). Associations were statistically significant for LUR NO X and CVD mortality (HR = 1.60; 95% CI: 1.08-2.37) and kriged NO 2 and breast cancer mortality (HR = 1.45; 95% CI 1.02-2.07). Gaseous and PM pollutants were positively associated with breast cancer mortality across racial/ethnic group.
Conclusion: In this study, air pollutants have a harmful impact on breast cancer survival. Additional studies should evaluate potential confounding by socioeconomic factors. These data support maintaining clean air laws to improve survival for women with breast cancer.
(Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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