Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features.

Autor: Hoffmann M; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Enczmann J; Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Balz V; Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Kummer S; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Reinauer C; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Döing C; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Förtsch K; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Welters A; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Kohns Vasconcelos M; Institute for Medical Microbiology and Hospital Hygiene, Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany; Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, United Kingdom., Mayatepek E; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Meissner T; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Jacobsen M; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany., Seyfarth J; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, 40225 Duesseldorf, Germany. Electronic address: julia.seyfarth@med.uni-duesseldorf.de.
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2022 Feb; Vol. 235, pp. 108928. Date of Electronic Publication: 2022 Jan 19.
DOI: 10.1016/j.clim.2022.108928
Abstrakt: High soluble IL-7 receptor (sIL-7R) serum levels and associated single nucleotide polymorphisms in the IL7RA gene were found in autoimmune diseases including type 1 diabetes. Further determinants on sIL-7R and IL-7 availability as well as changes during type 1 diabetes disease course remain elusive. Here we performed multiparameter analysis to identify influential genetic and disease-associated factors on sIL-7R and IL-7 serum levels during type 1 diabetes disease course (239 children) and in healthy controls (101 children). We found higher sIL-7R serum concentrations at type 1 diabetes onset and decreasing levels during therapy whereas IL-7 was only higher in long term patients as compared to controls. Multiple linear regression analyses revealed several factors, including IL7RA SNP rs6897932 and HLA risk haplotypes, influencing sIL-7R levels but not IL-7, which was solely associated with the sIL-7R. This study revealed unexpected complexity in the regulation of the sIL-7R but not for IL-7.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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